GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs891378 | 1 | rs10864175 | chr1:207433349 | CR2 | chr1:207627670-207663238:+ | 0.1 | 3.42 | 0.000639 | Spherical equivalent (joint main effects and education interaction) |
| BRCA | cis | rs891378 | 1 | rs10864178 | chr1:207445678 | CR2 | chr1:207627670-207663238:+ | 0.1 | 3.44 | 0.000594 | Spherical equivalent (joint main effects and education interaction) |
| BRCA | cis | rs6441961 | 1 | rs10865940 | chr3:46350367 | FYCO1 | chr3:45959396-46037307:- | -0.11 | -3.57 | 0.000372 | Celiac disease |
| BRCA | cis | rs7647973 | 1 | rs10865956 | chr3:49581559 | AMT | chr3:49454212-49460012:- | 0.13 | 4.54 | 6.31E-6 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs10865956 | chr3:49581559 | CCDC36 | chr3:49235861-49295537:+ | 0.11 | 4.08 | 4.9E-5 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs10865956 | chr3:49581559 | GMPPB | chr3:49758932-49761384:- | -0.12 | -3.53 | 0.000441 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs10865956 | chr3:49581559 | NCKIPSD | chr3:48711280-48723334:- | 0.14 | 3.59 | 0.000344 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs10865956 | chr3:49581559 | P4HTM | chr3:49027341-49044579:+ | 0.1 | 4.13 | 3.91E-5 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs10865956 | chr3:49581559 | WDR6 | chr3:49044637-49053386:+ | -0.14 | -4.11 | 4.25E-5 | Menarche (age at onset) |
| BRCA | cis | rs1031925 | 1 | rs10865970 | chr3:51357501 | GRM2 | chr3:51741081-51752623:+ | -0.18 | -3.44 | 0.000598 | Melanoma |
| BRCA | cis | rs10871290 | 1 | rs10871290 | chr16:74472696 | RFWD3 | chr16:74655298-74700779:- | 0.1 | 3.97 | 7.52E-5 | Breast cancer |
| BRCA | cis | rs239198 | 1 | rs10872623 | chr6:101165047 | ASCC3 | chr6:100956609-101329224:- | -0.08 | -3.44 | 0.000608 | Menarche (age at onset) |
| BRCA | cis | rs3931020 | 1 | rs10874122 | chr1:75235866 | CRYZ | chr1:75171175-75199092:- | -0.39 | -10.51 | 1.13E-24 | Resistin levels |
| BRCA | cis | rs10875746 | 1 | rs10875746 | chr12:48518264 | ASB8 | chr12:48541575-48551377:- | 0.14 | 4.06 | 5.37E-5 | Longevity (90 years and older) |
| BRCA | cis | rs1971762 | 1 | rs10876480 | chr12:54066271 | ATP5G2 | chr12:54058945-54070512:- | 0.09 | 3.37 | 0.000769 | Height |